7 research outputs found

    Wood Cityscapes: Mass Timber Office Building

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    Thesis (Master's)--University of Washington, 2015-12Most office building construction relies on steel and concrete for mid-high rise office building applications. The primary goal of this thesis is to understand the implications of CLT and mass timber construction systems for mid-high rise office buildings in Seattle by developing a prototypical office building located on a specific site. This research thesis will focus on comparing this prototypical mass timber office building design to the same/similar design using industry standard construction materials for Seattle. The criteria for comparison will include code, cost, schedule and greenhouse gas emissions

    Quality Assurance of Higher Education in the South Caucasus

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    ISSN:1867-932

    Reduction of Hospitalization and Mortality by Echocardiography-Guided Treatment in Advanced Heart Failure

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    In advanced heart failure (AHF) clinical evaluation fails to detect subclinical HF deterioration in outpatient settings. The aim of the study was to determine whether the strategy of intensive outpatient echocardiographic monitoring, followed by treatment modification, reduces mortality and re-hospitalizations at 12 months. Methods: 214 patients with ejection fraction 1 hospitalization during the last year underwent clinical evaluation and echocardiography at discharge and were divided into intensive (IMG; N = 143) or standard monitoring group (SMG; N = 71). In IMG, volemic status and left ventricular filling pressure were assessed 14, 30, 90, 180 and 365 days after discharge. HF treatment, particularly diuretic therapy, was temporarily intensified when HF deterioration signs and E/e’ > 15 were detected. In SMG, standard outpatient monitoring without obligatory echocardiography at outpatient visits was performed. Results: We observed lower hospitalization (absolute risk reduction [ARR]-0.343, CI-95%: 0.287–0.434, p p p < 0.05). Conclusion: In AHF, outpatient monitoring of volemic status and intracardiac filling pressures to individualize treatment may potentially reduce hospitalizations and mortality at 12 months follow-up. Echocardiography-guided outpatient therapy is feasible and clinically beneficial, providing evidence for the larger application of this approach

    Kinetics of Anti-Nucleocapsid IgG Response in COVID-19 Immunocompetent Convalescent Patients

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    International audienceAbstract The comprehension of a long-term humoral immune response against SARS-CoV-2 can shed light on the treatment and vaccination strategies of COVID-19 disease, improving the knowledge about this virus infection and/or re-infection. We assessed the IgG antibodies against SARS-CoV-2 nucleocapsid (N) protein (anti-SARS-CoV-2 (N) IgG) in 1441 COVID-19 convalescent patients within 15~months longitudinal study from middle-developed country. The main inclusion criteria was positive RT\textendash PCR result on nasopharyngeal swab samples at least one month before antibody testing and absence of any induced or inherited immunodeficiency. 92.7% of convalescent patients' serum contained anti-SARS-CoV-2 (N) IgG and only 1.3% of patients had a delayed antibody response. In the majority of convalescent patients' the durability of antibodies lasted more than one year. The kinetics of anti-SARS-CoV-2 (N) IgG took a bell-shaped character\textemdash increased first 25\textendash 30~weeks, then started to decrease, but were still detectable for more than 15~months. We found that on the one hand anti-SARS-CoV-2 humoral response level correlates with disease severity, on the other, in particular, the level of peak antibodies correlates with age\textemdash older patients develop more robust humoral response regardless of sex, disease severity and BMI
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